An Improved Implementation of Codon Adaptation Index

作者：Xia Xuhua^*

来源：Evolutionary Bioinformatics, 2007, 3: 53-58.

DOI：10.1177/117693430700300028

• Codon usage bias
• translation elongation
• gene expression
• tRNA

Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implementation to solve these problems. The improved CAI can predict protein production better than CAI from other commonly used implementations.

• 出版日期2007