科研之友
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摘要
A new procedure for the stereoselective synthesis of syn alpha-amino beta-oxy ketones is reported. It consists of two steps; in the first step, alpha-amino silyl enol ethers having a (Z) geometry are prepared from 1-alkynes via 1-sulfonyl-1,2,3-triazoles. In the second step, the silyl enol ethers undergo the TiCl4-mediated Mukaiyama aldol reaction with aldehydes to produce alpha-amino beta-oxy ketones with excellent syn-selectivity.
- 出版日期2014
