Stereoselective Synthesis of Polysubstituted Cyclopropanes from Poly(ethylene glycol) Supported Pyridinium Ylide

作者：Zhao Pan; Lu Cui-fen; Yang Gui-chun; Chen Zu-xing^*; Dong Nian-guo; Shi Jia-wei

来源：Chemical Research in Chinese Universities, 2011, 27(6): 984-987.

• Poly(ethylene glycol)
• Pyridinium ylide
• Synthesis
• Cyclopropane

Polysubstituted cyclopropanes were efficiently prepared with poly(ethylene glycol)(PEG) as soluble support. The reaction of PEG-supported pyridinium ylide with arylidenemalononitrilc(R=CN) or ethyl arylidenecyanoacetate(R=COOEt) in the presence of triethylamine(TEA) afforded PEG-supported cyclopropanecarboxylates, which were cleaved by 1% KCN/EtOH to obtain polysubstituted cyclopropanes with exclusive trans-selectivity and good yields.

• 出版日期2011-11
• 单位湖北大学