Potential cost-effectiveness of supervised injection facilities in Toronto and Ottawa, Canada

作者：Enns Eva A^*; Zaric Gregory S; Strike Carol J; Jairam Jennifer A; Kolla Gillian; Bayoumi Ahmed M

来源：Addiction, 2016, 111(3): 475-489.

DOI：10.1111/add.13195

• Harm reduction
• HCV
• HIV
• AIDS
• injection drug use
• mathematical modeling
• supervised injection facility

Background and AimsSupervised injection facilities (legally sanctioned spaces for supervised consumption of illicitly obtained drugs) are controversial public health interventions. We determined the optimal number of facilities in two Canadian cities using health economic methods.
DesignDynamic compartmental model of HIV and hepatitis C transmission through sexual contact and sharing of drug use equipment.
SettingToronto and Ottawa, Canada.
ParticipantsSimulated population of each city.
InterventionsZero to five supervised injection facilities.
MeasurementsDirect health-care costs and quality-adjusted life-years (QALYs) over 20years, discounted at 5% per year; incremental cost-effectiveness ratios.
FindingsIn Toronto, one facility cost $4.1 million and resulted in a gain of 385 QALYs over 20years, for an incremental cost-effectiveness ratio (ICER) of $10763 per QALY [95% credible interval (95CrI): cost-saving to $278311]. Establishing one facility in Ottawa had an ICER of $6127 per QALY (95CrI: cost-saving to $179272). At a $50000 per QALY threshold, three facilities would be cost-effective in Toronto and two in Ottawa. The probability that establishing three, four, or five facilities in Toronto was cost-effective was 17, 21, and 41%, respectively. Establishing one, two, or three facilities in Ottawa was cost-effective with 13, 35, and 41% probability, respectively. Establishing no facility was unlikely to be the most cost-effective option (14% in Toronto and 10% in Ottawa). In both cities, results were robust if the reduction in needle-sharing among clients of the facilities was at least 50% and fixed operating costs were less than $2.0 million.
ConclusionsUsing a $50000 per quality-adjusted life-years threshold for cost-effectiveness, it is likely to be cost-effective to establish at least three legally sanctioned spaces for supervised injection of illicitly obtained drugs in Toronto, Canada and two in Ottawa, Canada.

• 出版日期2016-3