An Economical Access to 3,4-Diaryl-2(5H)-furanones and 4-Aryl-6-methyl-2(2H)-pyranones by Pd-Catalyzed Suzuki-Type Arylation of 3-Aryl-4-tosyloxy-2(5H)-furanones and 6-Methyl-4-tosyloxy-2(2H)-pyranones, Respectively

作者：Bellina Fabio^*; Marchetti Chiara; Rossi Renzo

来源：European Journal of Organic Chemistry, 2009, 2009(27): 4685-4690.

DOI：10.1002/ejoc.200900581

• Synthetic methods
• C-C coupling
• Palladium
• Cross-coupling
• Heterocycles

Both symmetrical and unsymmetrical 3,4-diaryl-substituted 2(5H)-furanones have been efficiently synthesized using an inexpensive procedure involving the Pd(OAc)(2)/PCy(3)-catalyzed Suzuki-type arylation of readily available 3-aryl-4-tosyloxy-2(5H)-furanones as the key step. The mild conditions of this arylation protocol have also been used for the high yielding synthesis of 4-aryl-6-methyl-2(2H)-pyranones from 6-methyl-4-tosyloxy-2(2H)-pyranone.

• 出版日期2009-9