Assessment of the Relationship between Lipid Parameters and Obesity Indices in Non-Diabetic Obese Patients: A Preliminary Report

作者：Stepien Anna; Stepien Mariusz^*; Wlazel Rafal N; Paradowski Marek; Banach Maciej; Rysz Jacek

来源：MEDICAL SCIENCE MONITOR, 2014, 20: 2683-2688.

DOI：10.12659/msm.890845

• Dyslipidemias
• Obesity
• Therapeutics

Background: The aim of this cross-sectional study was to examine the relationship between obesity and lipid markers.
Material/Methods: We divided 66 non-diabetic adult obese patients (mean age: 55.8 +/- 11.6 years) into 3 groups according to body mass index (BMI). All patients were measured for waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI), and visceral adiposity index (VAI). Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were determined, and lipid indices TC/HDL, LDL/HDL, and TG/HDL were also estimated.
Results: TC and LDL-C in Group III were lower than in Group I (5.0 +/- 1.0 vs. 6.0 +/- 1.0 mmol/L, and 2.9 +/- 0.9 vs. 3.8 +/- 1.2 mmol/L; p<0.05 for both). Negative correlations were found between: BMI and TC, LDL, and HDL (r=-0.291; r=-0.310, r=-0.240, respectively); and WC, WHR, VAI, and HDL (r=-0.371, r=-0.296, r=-0.376, respectively). Positive correlations were found between WC, WHR, and TG/HDL (r=0.279, r=0.244, respectively) and between VAI and: TC (r=0.327), TG (r=0.885), TC/HDL (r=0.618), LDL/HDL (r=0.480), and TG/HDL (r=0.927).
Conclusions: Obesity is associated with lipid disturbances, especially with HDL-C reduction, in obese non-diabetic patients. VAI is strongly related to lipid profile and thus may be the most valuable obesity index in obese patients with dyslipidemias.

• 出版日期2014-12-16