Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren

作者：Barraza Villarreal Albino; Sunyer Jordi; Hernandez Cadena Leticia; Consuelo Escamilla Nunez Maria; Jose Sienra Monge Juan; Ramirez Aguilar Matiana; Cortez Lugo Marlene; Holguin Fernando; Diaz Sanchez David; Olin Anna Carin; Romieu Isabelle^*

来源：Environmental Health Perspectives, 2008, 116(6): 832-838.

DOI：10.1289/ehp.10926

• air pollution
• airway inflammation
• asthma
• epidemiology
• lung function
• schoolchildren

BACKGROUND: The biological mechanisms involved in inflammatory response to air pollution are not dearly understood.
OBJECTIVE: In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function.
METHODS: We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average of 22 weeks. We conducted spirometric tests, measurements of fractional exhaled nitric oxide (Fe(NO)), interleukin-8 (IL-8) in nasal lavage, and pH of exhaled breath condensate every 15 days during follow-up. Data were analyzed using linear mixed-effects models.
RESULTS: An increase of 17.5 mu g/m(3) in the 8-hr moving average of PM(2.5) levels (interquartile range) was associated with a 1.08-ppb increase in Fe(NO) [95% confidence interval (CI), 1.01-1.16] and a 1.07-pg/mL increase in IL-8 (95% CI 0.98-1.19) in asthmatic children and a 1.16 pg/ml increase in IL-8 (95% CI, 1.00-1.36) in nonasthmatic children. The 5-day accumulated average of exposure to particulate matter < 2.5 pm in aerodynamic diamter (PM(2.5)) was significantly inversely associated with forced expiratory volume in 1 see (FEV(1)) (p = 0.048) and forced vital capacity (FVC) (p = 0.012) in asthmatic children and with FVC (p = 0.021) in nonasthmatic children. FeNO and FEV(1) were inversely associated (p = 0.005) in asthmatic children.
CONCLUSIONS: Exposure to PM(2.5) resulted in acute airway inflammation and decrease in lung function in both asthmatic and nonasthmatic children.

• 出版日期2008-6