A Simple PLGA-AgNPL Film for Antibiofilm Formation by Contact Bactericidal Activity

作者：Kyaw Kaung; Motoyama Nana; Ichimaru Hiroaki; Harada Ayaka; Morimura Shigeru; Ono Katsuhiko; Tsutsuki Hiroyasu; Sawa Tomohiro; Miyazawa Yuta; Mizoguchi Daigou; Niidome Takuro^*

来源：Chemistry Letters, 2018, 47(3): 308-310.

DOI：10.1246/cl.171022

• Antibiofilm formation
• Silver nanoplate
• Antibacterial coating

A PLGA-AgNPL film was fabricated to demonstrate antibiofilm formation activity against Staphylococcus aureus. The film with a PLGA concentration of 25 mgmL(-1) with 0.1% silver nanoplates showed promising (94%) reduction of biofilm formation. The PLGA-AgNPL film did not produce many silver ions. The mode of action of the film was hypothesized to be contact killing when bacteria were attached to the surface to commence biofilm formation.

• 出版日期2018-3