Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

作者：Niemeyer Daniela; Zillinger Thomas; Muth Doreen; Zielecki Florian; Horvath Gabor; Suliman Tasnim; Barchet Winfried; Weber Friedemann; Drosten Christian^*; Mueller Marcel A

来源：Journal of Virology, 2013, 87(22): 12489-12495.

DOI：10.1128/JVI.01845-13

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

• 出版日期2013-11