Double Modification of Polymer End Groups through Thiolactone Chemistry

作者：Driessen Frank; Martens Steven; De Meyer Bernhard; Du Prez Filip E^*; Espeel Pieter^*

来源：Macromolecular Rapid Communications, 2016, 37(12): 947-951.

DOI：10.1002/marc.201600150

• amine-thiol-ene conjugation
• end group functionalities
• one-pot double modification
• polymer-polymer conjugation

A straightforward synthetic procedure for the double modification and polymer-polymer conjugation of telechelic polymers is performed through amine-thiol-ene conjugation. Thiolactone end-functionalized polymers are prepared via two different methods, through controlled radical polymerization of a thiolactone-containing initiator, or by modification of available end-functionalized polymers. Next, these different linear polymers are treated with a variety of amine/acrylate-combinations in a one-pot procedure, creating a library of tailored end-functionalized polymers. End group conversions are monitored via SEC, NMR, and MALDI-TOF analysis, confirming the quantitative modification after each step. Finally, this strategy is applied for the synthesis of block copolymers via polymer-polymer conjugation and the successful outcome is analyzed via LCxSEC measurements.

• 出版日期2016-6