Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension

作者：Fang, Jinrui; Ma, Liya^*; Zhang, Shuhong; Fang, Yan; Su, Peng; Ma, Huiyuan

来源：Molecular Medicine Reports, 2013, 7(1): 313-317.

DOI：10.3892/mmr.2012.1143

• essential hypertension
• gene polymorphism
• myeloperoxidase
• genetic susceptibility
• carotid artery ultrasound
• atherosclerosis

The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the occurrence of plaque in the carotid artery in the AS group was higher compared to the non-AS group. The frequency of the GC genotype in the AS group was significantly higher compared to the non-AS group. The frequency of carotid AS is higher in patients with hypertension, which is related to the MPO gene polymorphism.

• 出版日期2013-1
• 单位甘肃省人民医院