A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding igand

作者:Arachchilage Gayan Mirihana; Morris Mark J; Basu Soumitra*
来源:Chemical Communications, 2014, 50(10): 1250-1252.
DOI:10.1039/c3cc47381c

摘要

An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effective strategy for identification of potential intracellular G-quadruplex targets for a ligand.

  • 出版日期2014