A new family of covariate-adjusted response adaptive designs and their properties

作者：Zhang Li-Xin^*; Hu Fei-fang

来源：Applied Mathematics. Series B, A Journal of Chinese Universities, 2009, 24(1): 1-13.

DOI：10.1007/s11766-009-0001-6

• adaptive design
• covariate
• efficiency
• asymptotic variability

It is often important to incorporate covariate information in the design of clinical trials. In literature there are many designs of using stratification and covariate-adaptive randomization to balance certain known covariate. Recently, some covariate-adjusted response-adaptive (CARA) designs have been proposed and their asymptotic properties have been studied (Ann. Statist. 2007). However, these CARA designs usually have high variabilities. In this paper, a new family of covariate-adjusted response-adaptive (CARA) designs is presented. It is shown that the new designs have less variables and therefore are more efficient.

• 出版日期2009-3
• 单位浙江大学