An ultrasensitive electrochemiluminescence sensor for detecting diphenhydramine hydrochloride based on L-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles nanocomposites

作者：Miao, Chongchong; Zhang, Amin; Xu, Yanan; Chen, Shen; Ma, Feimeng; Huang, Chusen; Jia, Nengqin^*

来源：Sensors and Actuators B: Chemical , 2015, 213: 5-11.

DOI：10.1016/j.snb.2015.02.069

• Electrochemiluminescence sensor
• Tris(2,2 '-bipyridyl)dichlororuthenium(II) hexahydrate
• MWCNTs-Cys-AuNPs
• Diphenhydramine hydrochloride detection
• Pharmaceutical analysis

Anew electrochemiluminescence (ECL) sensor was constructed for the ultrasensitive detection of diphenhydramine hydrochloride (DPH) based on L-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles (MWCNTs-Cys-AuNPs) nanocomposites. In this work, the nanocomposites were facilely synthesized by using L-cysteine as linking agent which could covalently conjugate to MWCNTs and AuNPs via amide bond and Au-S bond. Herein, the prepared MWCNTs-Cys-AuNPs were used as matrix material and fixed by Nafion to adsorb Ru(bpy)(3)(2+) on glassy carbon electrode (GCE) to provide a new ECL sensor for DPH. Then the electrochemical and ECL behaviors of the sensor were investigated. Approximate 9-fold enhancement in ECL intensity was observed after addition of DPH. By optimizing the experimental conditions, the proposed ECL sensor exhibited excellent assay performances in determination of DPH with a wide linear range (2 x 10(-8)-7.5 x 10(-4) M), low detection limit (6.7 x 10(-9) M), good reproducibility and acceptable stability. Furthermore, the constructed ECL sensor was used to analyze the DPH in real sample with a satisfactory result, which holds a great potential in the field of pharmaceutical analysis.

• 出版日期2015-7-5
• 单位上海师范大学