An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6-to 18-month-old underweight children in rural Malawi

作者：Thakwalakwa Chrissie M; Ashorn Per; Jawati Mpumulo; Phuka John C; Cheung Yin Bun; Maleta Kenneth M^*

来源：Public Health Nutrition, 2012, 15(9): 1755-1762.

DOI：10.1017/S1368980012003023

• Corn-soya blend
• Lipid-based nutrient supplement
• Undernutrition
• Infant

Objective: To determine if supplementation with corn-soya blend (CSB) or lipid-based nutrient supplement (LNS) improved the weight gain of moderately underweight infants and children when provided through the national health service. %26lt;br%26gt;Design: A randomised, controlled, assessor-blinded clinical trial. Infants and children were randomised to receive for 12 weeks an average daily ration of 71 g CSB or 43 g LNS, providing 1188 kJ and 920 kJ, respectively, or no supplement (control). Main outcome was weight gain. Secondary outcomes included changes in anthropometric indices and incidence of serious adverse events. Intention-to-treat analyses were used. %26lt;br%26gt;Setting: Kukalanga, Koche, Katema and Jalasi health centres in Mangochi District, rural Malawi. %26lt;br%26gt;Subjects: Underweight (weight-for-age Z-score %26lt; -2) infants and children aged 6-15 months (n 299). %26lt;br%26gt;Results: Mean weight gain was 630 g, 680 g and 750 g in control, CSB and LNS groups, respectively (P = 0.21). When adjusted for baseline age, children receiving LNS gained on average 90g more weight (P = 0.185) and their weight-for-length Z-score increased 0.22 more (P = 0.049) compared with those receiving no supplementation. No statistically significant differences were observed between the CSB and control groups in mean weight and length gain. %26lt;br%26gt;Conclusions: LNS supplementation provided during the lean season via through the national health service was associated with a modest increase in weight. However, the effect size was lower than that previously reported under more controlled research settings.

• 出版日期2012-9