Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

作者：Liu, Ming; Li, Bin; Guo, Wen; Zhang, Xiyang; Chen, Zhengshuai; Li, Jingjie; Yan, Mengdan; Chen, Chao^*; Jin, Tianbo^*

来源：Oncotarget, 2016, 7(34): 54771-54781.

DOI：10.18632/oncotarget.10754

• association study
• breast cancer
• TSPYL6
• single nucleotide polymorphism

We investigated the associations between single nucleotide polymorphisms ( SNPs) in the testis-specific Y-encoded-like protein 6 ( TSPYL6) gene and breast cancer ( BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios ( ORs) and 95% confidence intervals ( 95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.

• 出版日期2016-8-23
• 单位西安交通大学; 内蒙古医科大学; 西北大学