科研之友
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摘要
BackgroundAttention-deficit hyperactivity disorder (ADHD) is the most common neurobehavioral disorder of childhood, affecting 5-8% of children. It has been observed that these children have poor sedation experiences; however, to date there is minimal research on procedural sedation in this population. AimTo examine whether children with ADHD required larger doses of propofol for magnetic resonance imaging (MRI) sedation. MethodsThe hospital's administrative billing database was used to identify all billing codes for MRI brain scans (with and without contrast) in children aged between 5 and 12years over the preceding 5.5years. The hospital's electronic medical record database provided baseline demographics. The sedation record was reviewed for propofol dose, psychostimulant use, and prescribed dose. All children received a standard weight-based dose of midazolam prior to receiving the necessary amount of propofol. Primary outcome was the dose of propofol administered (mgkg(-1)) to achieve adequate sedation. ResultsA total of 258 procedures met the inclusion criteria. The sample was 52% male, 74% White, 7.8% Black, 7.8% Hispanic, 4.3% Asian, and 6.2% other. ADHD was documented for 49 procedures with a prevalence of 18.5%. Patients with ADHD were older, more likely to be male, Hispanic, or to report race as Refused/Unknown'. Indications for MRI for patients with ADHD varied significantly, with Behavioral' and Neurocutaneous' being significantly overrepresented in the ADHD group. The average sedative dose for all patients was 2.8mgkg(-1) (95% CI 2.62-2.94). Sedative dose was similar among children with and without ADHD diagnosis. ConclusionsOur study illustrates that children with ADHD do not have higher sedative requirements to achieve a successful brain MRI.
- 出版日期2015-10
