A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

作者:Kim Taeyoung; Jeon Hyun Mi; Le Hoa Thi; Kim Tae Woo; Kang Chulhun*; Kim Jong Seung
来源:Chemical Communications, 2014, 50(57): 7690-7693.
DOI:10.1039/c4cc02878c

摘要

Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

  • 出版日期2014