Avoiding Androgen Deprivation Therapy in Men With High-risk Prostate Cancer: The Role of Radical Prostatectomy as Initial Treatment

作者：Miocinovic Ranko; Berglund Ryan K^*; Stephenson Andrew J; Jones J Stephen; Fergany Amr; Kaouk Jihad; Klein Eric A

来源：Urology, 2011, 77(4): 946-950.

DOI：10.1016/j.urology.2010.11.057

OBJECTIVE To examine the ability of surgery as initial management in avoiding androgen deprivation therapy (ADT) in patients with high-risk localized prostate cancer.
MATERIALS AND METHODS A total of 267 men were identified from a cohort of patients treated by radical prostatectomy (RP) between January 1998 and June 2004. Patients were included if they presented with clinical stage >= T2b and/or prostate-specific antigen (PSA) >= 15 ng/mL, and/or Gleason score >= 8. Information on biochemical recurrence, distant metastasis, cancer-specific survival, and use of ADT was obtained from a prospectively maintained database.
RESULTS The median follow-up was 6.7 years (range, 1-146 months). Biochemical recurrence (BCR), distant metastasis (DM), and prostate cancer-specific mortality (PCSM) were observed in 112 (42%), 28 (10%), and 15 (6%) patients, respectively. Salvage treatment was performed in 95 (85%) of 112 patients with BCR. Only 71 (27%) of 267 men were subjected to ADT. Overall, 8-year probabilities of freedom from BCR, DM, PCSM, and ADT were 46% (95% CI, 38-54), 87% (95% CI, 84-90), 93% (95% CI, 91-95), and 71% (95% CI, 65-77), respectively.
CONCLUSIONS RP provides excellent long-term clinical outcomes for patients with high-risk localized prostate cancer and avoids the use of ADT in approximately 70% of these patients. UROLOGY 77: 946-951, 2011.

• 出版日期2011-4