Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race

作者：Bundy Vanessa; Johnson Maribeth; Gutin Bernard; Zhu Haidong; Stallmann Jorgensen Inger; Dong Yanbin^*

来源：Journal of Pediatric Endocrinology & Metabolism, 2011, 24(3-4): 119-124.

DOI：10.1515/JPEM.2011.036

• adiponectin
• adolescents
• leptin
• percent body fat

Objectives: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships.
Methods : Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays.
Results : Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p=0.0017) and black girls had the highest leptin (p=0.0164). Percent BF and leptin were positively correlated (p=0.0164). The %BF-leptin relationship was stronger in boys than girls (p<0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p=0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender.
Conclusion : Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.

• 出版日期2011-4