Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transition

作者：Park Soyoung; Otomo Haruka; Zheng Linjie; Sugiyama Hiroshi^*

来源：Chemical communications, 2014, 50(13): 1573-1575.

DOI：10.1039/c3cc48297a

A 2-aminothieno[3,4-d] pyrimidine G-mimic deoxyribonucleoside, thdG, was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that thdG enables the visual detection of Z-DNA successfully based on different pi-stacking of B- and Z-DNA.

• 出版日期2014