Association between Delirium and Prehospitalization Medication in Poststroke Patients

作者：Hosoya Ryuichiro; Sato Yohei; Ishida Emika; Shibamoto Haruna; Hino Seiichi; Yokote Hiroaki; Kamata Tomoyuki

来源：Journal of Stroke and Cerebrovascular Diseases, 2018, 27(7): 1914-1920.

DOI：10.1016/j.jstrokecerebrovasdis.2018.02.038

• Derilium
• stroke
• medication
• polypharmacy
• sleeping pill

Purpose: Medication is an important risk factor for delirium; however, the association between delirium and prehospitalization medication is unclear. We investigated the association between prestroke medication and poststroke delirium. Materials and Methods: All patients hospitalized in the stroke care unit from September 2011 to September 2012 were selected, and their delirium symptoms, patient information, and pre- and poststroke medications were analyzed. Delirium was defined as a score of 4 or higher on the Intensive Care Delirium Screening Checklist. Factors that were related to delirium were extracted using univariate analysis, and the independent risk factors were determined using multivariate analysis. Results: Of the 269 patients analyzed, 97 (36%) experienced delirium. Univariate analysis revealed significant differences between the delirium and nondelirium groups in age, dementia, previous cerebrovascular disease, craniotomy, all insertion-tube types, and 6 categories of prestroke medication. Prestroke polypharmacy was associated with poststroke delirium (P = .002). Multivariate analysis showed that taking antianxiety agents or sleep aids was an independent risk factor for delirium (odds ratio: 3.17, 95% confidence interval: 1.16-8.82). Conclusions: The present study suggests that prestroke medication affects the onset of poststroke delirium. These findings can contribute to the prediction and prevention of this condition.

• 出版日期2018-7