科研之友
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摘要
The remarkable recent discoveries of the proteins mediating mitochondrial Ca2+ transport (reviewed in this issue) provide an exciting opportunity to utilise this new knowledge to improve our fundamental understanding of relationships between Ca2+ signalling and bioenergetics and, importantly, to improve the understanding of diseases in which Ca2+ toxicity and mitochondrial malfunction play a crucial role. Ca2+ is an important activator of exocrine secretion, a regulator of the bioenergetics of exocrine cells and a contributor to exocrine cell damage. Exocrine secretory cells, exocrine tissues and diseases affecting exocrine glands (like Sjogren%26apos;s syndrome and acute pancreatitis) will, therefore, provide worthy research areas for the application of this new knowledge of the Ca2+ transport mechanisms in mitochondria.
- 出版日期2012-7
