Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells

作者：Choi Eun Mi^*

来源：European Journal of Pharmacology, 2011, 664(1-3): 1-7.

DOI：10.1016/j.ejphar.2011.05.005

• Dehydrocostus lactone
• Mitochondrial dysfunction
• Osteoblastic MC3T3-E1 cells

The dried root of Saussurea lappa Clarke (Compositae) has been used as a traditional medicine. Dehydrocostus lactone is one of the main bioactive constituents of this medicinal plant. In the present study, the protective effect of dehydrocostus lactone against antimycin A (an inhibitor of mitochondrial complex III)-induced cytotoxicity was investigated in osteoblastic MC3T3-E1 cells. Pre-treatment with dehydrocostus lactone prior to antimycin A exposure significantly prevented mitochondrial membrane potential dissipation, complex IV inactivation, ATP loss, cytochrome c release, intracellular calcium elevation and potassium loss, and reactive oxygen species production induced by antimycin A. These results suggest that dehydrocostus lactone protects osteoblastic MC3T3-E1 cells from antimycin A-induced cell damage through the improved mitochondrial function.

• 出版日期2011-8-16