A Trimeric Proanthocyanidin from the Bark of Acacia leucophloea Willd.

作者：Ahmed Sarfaraz^*; Lin Hsiao Ching; Nizam Iram; Khan Nadeem Ahmad; Lee Shoei Sheng; Khan Nizam Uddin

来源：Records of Natural Products, 2014, 8(3): 294-298.

• Acacia leucophloea
• Mimosaceae
• alpha-Glucosidase inhibitor
• proanthocyanidin

(-)-Fisetinidol-(4 alpha,8)-[(-)-fisetinidol-(4 alpha,6)]-(+)-catechin (1), a proanthocyanidin, was isolated from the bark of Acacia leucophloea. Its structure including absolute configuration was elucidated on the basis of spectroscopic analysis and chemical correlation. The H-1 NMR spectrum of this compound, exhibiting exceptional complex signals attributable to rotational isomerism, and the reported data were obtained at elevated temperature in methyl ether acetate form. This work provided the H-1 and C-13 NMR assignments for 1 and its rotational isomer as the free phenolic form at ambient temperature for the first time. Compound 1 showed inhibitory activity against alpha-glucosidase type IV from Bacillus stearothermophilus with the IC50 value of 102.3 mu M.

• 出版日期2014