科研之友
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摘要
MUCI is a large trans-membrane highly glycosylated mucin which is expressed at the apical pole of normal cells in glandular epithelia. MUCI is implicated in many physiological mechanisms such as adhesion, development and differentiation. Also, MUCI is frequently deregulated and over-expressed with a membrane circumferential and/or cytoplasmic expression. The intracellulor tail of MUCI is phosphorylated and can interact with many signalling proteins and transcriptional factors. Indeed, MUCI can interact with beta-cotenin competitively for E-cadherin, thus destabilizing intercellular junctions and favouring metastatic dissemination. In carcinomas, the overexpression and membrane delocolization of MUCI is associated with a worse prognosis and a shorter survival in breast, colon, kidney, prostate or gastro-intestinal cancers. MUCI appears to be a novel therapeutic target for immunotherapy or anti-tumour vaccines.
- 出版日期2006-9
