Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer%26apos;s disease

作者：Feher Agnes^*; Juhasz Anna; Pakaski Magdolna; Kalman Janos; Janka Zoltan

来源：Neuroscience Letters, 2012, 526(1): 20-23.

DOI：10.1016/j.neulet.2012.08.010

• Alzheimer%26apos
• s disease
• 24-Dehydrocholesterol reductase (DHCR24)
• Seladin-1 (selective AD indicator)
• Single nucleotide polymorphism (SNP)
• rs600491
• Apolipoprotein E4 (APOE)

A remarkable candidate gene for late-onset Alzheimer%26apos;s disease (AD) is 24-dehydrocholesterol reductase (DHCR24) gene that encodes seladin-1 (selective AD indicator), an enzyme that is involved in the cholesterol biosynthetic pathway, exerts neuroprotective and anti-apoptotic effects, and found to be down regulated in AD vulnerable brain regions. %26lt;br%26gt;The genetic association between DHCR24 rs600491 polymorphism and the risk for AD was investigated in 295 Hungarian late-onset AD patients and 204 ethnically matched, elderly, cognitively healthy control individuals. %26lt;br%26gt;The DHCR24 rs600491 genotype distributions did not differ significantly between the AD and control groups. Stratification according to gender, however, revealed a statistically significant association between T/T genotype and AD risk in men, in contrast with the results in women. Our findings indicate a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to AD.

• 出版日期2012-9-20