An easy route toward enantio-enriched polycyclic derivatives via an asymmetric domino conjugate reduction-aldol cyclization catalyzed by a chiral Cu(I) complex

作者：Deschamp Julia; Hermant Thomas; Riant Olivier^*

来源：Tetrahedron, 2012, 68(17): 3457-3467.

DOI：10.1016/j.tet.2011.07.039

• Asymmetric Catalysis
• Copper(I)
• Reductive-aldol cyclization
• Polycyclic compounds

A highly efficient reductive-aldol cyclization mediated by a chiral Cu(I) complex and an organosilane yielded to cyclic or polycyclic derivatives. An excellent control of the selectivities was reached in most cases (dr up to 100:0 and ee up to 95%). After developing the enantioselective intramolecular reductive-aldol methodology, this strategy was successfully used for the synthesis of a key intermediate of a natural diterpene in few steps.

• 出版日期2012-4-29