Asymmetric Mukaiyama Aldol Reaction Catalyzed by C-2-Symmetric N,N '-Dioxide-Ni(II) Complex

作者：Zhao, Jiannan; Zheng, Ke; Yang, Yang; Shi, Jian; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming^*

来源：Synlett, 2011, (7): 903-906.

DOI：10.1055/s-0030-1259698

• asymmetric catalysis
• N,N '-dioxides complex
• nickel
• Mukaiyama aldol reaction
• glyoxal derivatives

The N,N'-dioxide-Ni(II) complex has been developed for the asymmetric Mukaiyama aldol reaction between glyoxal derivatives and enolsilane which produced the 2-hydroxy-1,4-dicarbonyl compounds in moderate to high yields (up to 95%) with excellent enantioselectivities (up to 95% ee). Based on the configuration of the product and X-ray structure of the catalyst, a possible transition state was proposed to explain the mechanism of the reaction.

• 出版日期2011-4
• 单位四川大学