Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants

作者：Stangeland Torunn^*; Wangensteen Helle; Katuura Esther; Lye Kare A; Paulsen Berit S

来源：Journal of Medicinal Plants Research, 2010, 4(18): 1916-1923.

• Hallea rubrostipulata
• Vernonia adoensis
• Zanthoxylum chalybeum
• 2,2-Diphenyl-1-picrylhydrazyl
• fluorescence recovery after photobleaching
• total phenolic compounds

Extracts from three plants; Hallea rubrostipulata, Vernonia adoensis and Zanthoxylum chalybeum, were tested for antioxidant activity using three assays 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Ability of Plasma (FRAP) and total phenol content) and anti-plasmodial activity using an Enzyme-Linked Immunosorbent Assay (ELISA) on Plasmodium falciparum chloroquine sensitive strain MRA-285 line. The objective of the study was to find candidates for making anti-malarial phytomedicines. The water extract of H. rubrostipulata showed very high anti-plasmodial activity (IC(50) = 1.95 mu g/ml) and high antioxidant activity as well. Thirteen other extracts had high anti-plasmodial activity ranging from 2.14 to 3.63 mu g/ml (chloroquine IC50= 8 mu g/ml). We found high correlation between the different antioxidant assays.

• 出版日期2010-9-18