An efficient synthesis of 6,9-disubstituted purin-8-ones via copper-catalyzed coupling/cyclization

作者：Zhong, Qi-Fei; Sun, Li-Ping^*

来源：Tetrahedron, 2010, 66(27-28): 5107-5111.

DOI：10.1016/j.tet.2010.04.106

• Purin-8-ones
• Copper-catalyzed coupling/cyclization
• Microwave-assisted synthesis

An efficient and novel synthesis of 6,9-disubstituted purin-8-ones has been developed. Starting from dichloropyrimidin-5-ylcarbamate, CuCl/amino acid catalyzed coupling/cyclization reaction with amines was achieved to afford 9-substituted 6-chloropurin-8-ones. Then a microwave-assisted amination procedure was carried out for the synthesis of 6,9-disubstituted purin-8-ones in moderate to good yields.

• 出版日期2010-7-3
• 单位中国药科大学