Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate

作者：Alexandrova Anastasia V; Beier Petr^*

来源：Journal of Fluorine Chemistry, 2009, 130(5): 493-500.

DOI：10.1016/j.jfluchem.2009.02.015

• Phosphonates
• Phosphates
• Difluoromethylenation
• Nucleophilic addition

A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols.

• 出版日期2009-5