Association of blood pressure in the supine position with target organ damage in subjects over 60 years old

作者：Wang, Feng; Zhao, Hualing; Yang, Chao; Kong, Guilan; Song, Lu; Li, Chunhui; Wang, Yiming; Chen, Shuohua; Wang, Jing^*; Wu, Shouling

来源：Journal of International Medical Research, 2017, 45(1): 123-133.

DOI：10.1177/0300060516677175

• Aged
• arteriosclerosis
• hypertension
• supine position
• renal insufficiency
• chronic

Objective: To explore the correlation between blood pressure in the supine position and target organ damage in subjects over 60 years of age. @@@ Methods: In 2444 individuals, we investigated the association of systolic blood pressure (SBP) in the supine position with the target organ damage indices microalbuminuria (ALBU), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (IMT). Supine hypertension (SH) is defined as systolic blood pressure >= 140mmHg and/or diastolic blood pressure >= 90 mmHg. Subjects were assigned to either the SH group (1275 cases) or the non-SH group (1169 cases). @@@ Results: The levels of ALBU, baPWV, and IMT, as well as the percentage of participants with ALBU> 30 mg/L, baPWV >= 1400 cm/s, and IMT >= 1 mm, were significantly higher in the SH group than in the non-SH group. Multivariate logistic regression analysis showed that SH was an independent risk factor for baPWV and IMT, but the relationship with ALBU was not statistically significant after correction for confounding factors. @@@ Conclusions: SH is a risk factor for target organ damage, as expressed by the indices baPWV and IMT. The association of SH with kidney damage requires further study.

• 出版日期2017-2
• 单位北京大学; 中国科学技术大学; 华北理工大学