Antigen-based immunotherapy (AIT) for autoimmune and allergic disease

作者：MacLeood Megan K L^*; Anderton Stephen M

来源：Current Opinion in Pharmacology, 2015, 23: 11-16.

DOI：10.1016/j.coph.2015.05.003

Autoimmune and allergic diseases are major causes of morbidity. Antigen-based immunotherapy (AID is immunologically the most satisfying means of specifically targeting only those T cells driving disease, thereby inducing antigen-specific immune tolerance, with the lowest adverse risk profile. AIT is highly effective in rodent models of T cell-driven inflammation and is now in clinical trials. The range of approaches to applying All in the clinic prevents a consensus on the molecular basis for this form of tolerance. In particular, there has been a paucity of information on how pre-activated effector and memory T cells respond to AIT. New, advanced murine models of AIT are beginning to deliver such information at the cellular, biochemical, transcriptional and epigenetic levels.

• 出版日期2015-8