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摘要
A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.
- 出版日期2015-10-12
