Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: Comparing treatment with risperidone and haloperidol

作者：Riedel Michael; Mayr Andreas; Seemueller Florian; Maier Wolfgang; Klingberg Stefan; Heuser Isabella; Klosterkoetter Joachim; Gastpar Markus; Schmitt Andrea; Sauer Heinrich; Schneider Frank; Gaebel Wolfgang; Jaeger Markus; Moeller Hans Juergen; Schennach Wolff Rebecca^*

来源：World Journal of Biological Psychiatry, 2012, 13(1): 30-38.

DOI：10.3109/15622975.2011.552633

• First-episode schizophrenia
• depressive symptoms
• early response
• response
• remission

Objective. To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol. Method. A total of 274 patients were analysed within a double-blind randomized controlled trial and treated with risperidone or haloperidol. The patients were grouped according to their baseline HAMD-21 total score in a %26quot;depressed%26quot; (HAMD-21 %26gt;= 16) or %26quot;non-depressed%26quot; (HAMD-21 %26lt; 16) patient subgroup. PANSS, HAMD-21, GAF, SOFAS and AIMS ratings were performed. Early response was defined as an initial 20% reduction of the PANSS total score from admission to week 2, response as an at least 50% reduction of the PANSS total score from admission to discharge and remission according to the consensus criteria. Results. A total of 124 patients were classified as depressive at baseline with 22 patients still being depressive at discharge. The depressed and non-depressed patients did not significantly differ regarding the treatment with risperidone and haloperidol (P = 0.2270). The depressive patients suffered from significantly more suicidal tendencies (P = 0.0165), had significantly less insight into their illness (P = 0.0152) and featured significantly worse functioning (P = 0.0066). Patients with depressive symptoms achieved remission significantly less often than non-depressed patients. Conclusion. The importance of a specific and adequate treatment of depressive symptoms is highlighted.

• 出版日期2012-1
• 单位上海市精神卫生中心