Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors

作者：Winkler Jeffrey D^*; Isaacs Andre K; Xiang Chaomei; Baubet Valerie; Dahmane Nadia

来源：Tetrahedron, 2011, 67(52): 10261-10266.

DOI：10.1016/j.tet.2011.10.028

• Cyclopamine
• Steroidal alkaloid
• Cancer chemotherapy
• Hedgehog signaling
• Structure-activity relationships

The design, synthesis, and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a hedgehog signaling inhibitor, are described. Structure-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.

• 出版日期2011-12-30