Model-based inversion of ultrasonic guided waves for cortical bone properties

作者：Tho N., Tran; Mauricio D., Sacchi; Dean, Ta; Vu-Hieu, Nguyen; Lawrence H., Le

来源：Journal of the Acoustical Society of America, 2018, 144(3_Supplement): 1821-1821.

DOI：10.1121/1.5068030

<jats:p>Axial transmission ultrasonography, which uses a set of transmitting and receiving probes placed on the same waveguide’s surface, shows the potential clinical application for cortical bone quality assessment. In this work, a model-based parameter sweep inversion approach has been developed to estimate the thickness and elastic velocities of the cortex from the dispersive axially-transmitted snapshots. The inversion algorithm is formulated in the frequency-phase velocity (f-c) domain. To solve the inverse problem, i.e., to extract bone properties from ultrasound data, a forward modeling has been developed to simulate the f-c dispersion curves given a bone model. A semi-analytical finite element (SAFE) method is used to compute the dispersion curves for a complex structure of a cortical bone plate coupled with overlying soft tissues. A parameter sweep is used to seek within a range of values an optimized solution with the least misfit. The proposed method optimizes the mismatch between the measured and theoretically calculated dispersion curves with a least-square constraint. Numerical and in-vivo experimental data examples are presented to illustrate the technique’s performance.</jats:p>

• 出版日期2018-9-1
• 单位复旦大学