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摘要
An efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline and 1,8-dioxohexahydroacridine derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with (a) cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate, and (b) 2 equivalents of cyclic 1,3-dicarbonyl compounds in the presence of novel polymeric catalyst [poly(AMPS-co-AA)] under solvent-free conditions. The present approach offers several advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst.
- 出版日期2012
