Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents

作者：Wattez Jean Sebastien; Ravallec Rozenn; Cudennec Benoit; Knauf Claude; Dhulster Pascal; Valet Philippe; Breton Christophe; Vieau Didier; Lesage Jean^*

来源：Peptides, 2013, 48: 134-136.

DOI：10.1016/j.peptides.2013.08.005

• Apelin
• Cholecystokinin
• Glucagon-like peptide 1
• STC-1 cells
• Rat

Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1.

• 出版日期2013-10