An Extracellular Matrix-Mimicking Hydrogel for Full Thickness Wound Healing in Diabetic Mice

作者：Qin, Xianyan; Qiao, Weizhen; Wang, Yuejing; Li, Tingyu; Li, Xiang; Gong, Tao; Zhang, Zhi-Rong; Fu, Yao^*

来源：Macromolecular Bioscience, 2018, 18(7): 1800047.

DOI：10.1002/mabi.201800047

• anti-inflammation
• diabetic wound healing
• extracellular matrix
• hydrogel

An extracellular matrix-mimicking hydrogel is developed consisting of a hyaluronan-derived component with anti-inflammatory activity, and a gelatin-derived component offering adhesion sites for cell anchorage. The in situ-forming hyaluronan-gelatin (HA-GEL) hydrogel displays a sponge-like microporous morphology. Also, HA-GEL shows a rapid swelling pattern reaching maximum weight swelling ratio within 10 min, while at the equilibrium state, fully swollen hydrogels display an exceedingly high water content with approximate to 2000% of the dry gel weight. Under typical 2D cell culture conditions, murine 3T3 fibroblasts adhere to, and proliferate on top of the HA-GEL substrates, which demonstrate that HA-GEL provides a favorable microenvironment for cell survival, adhesion, and proliferation. In vivo healing study further demonstrates HA-GEL as a viable and effective treatment option to improve the healing outcome of full thickness wounds in diabetic mice by effectively depleting the inflammatory chemokine monocyte chemoattractant protein-1 in the wound bed.

• 出版日期2018-7
• 单位四川大学