A Transmembrane Polymorphism of Fc gamma Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis

作者：Mo, Na; Lai, Ruogu; Luo, Shizi; Xie, Jianglin; Wang, Xizi; Liu, Lijuan; Liu, Xiaoling; Chen, Guangxing^*

来源：Evidence-Based Complementary and Alternative Medicine, 2016, 2016: 3214657.

DOI：10.1155/2016/3214657

• SYSTEMIC-LUPUS-ERYTHEMATOSUS
• CD32B
• AUTOIMMUNITY
• ANTIBODIES
• FCGR2B

Objective. The purpose is to investigate the role of kidney deficiency and the association between kidney deficiency and a polymorphism Fc gamma RIIb 695T>C coding for nonsynonymous substitution IIe232Thr (I232T) in rheumatoid arthritis (RA). Methods. Clinical parameters and autoantibodies were analyzed and genotyping was performed in 159 kidney deficiency and 161 non-kidney-deficiency RA patients. Results. The age of disease onset and disease duration exhibited significant differences between two groups (P < 0.01). Patients with kidney deficiency tend to have higher activity of disease (P < 0.05). Anti-cyclic citrullinated peptides antibodies (ACPA) levels of patients with kidney deficiency were higher than the controls (P = 0.039). 125 (78.6%) kidney deficiency and 114 (70.8%) non-kidney-deficiency patients had both ACPA-positive and RF-positive (P = 0.04, OR = 3.29). Fc gamma RIIb I232TT homozygotes were identified in 10 of 159 (6.3%) kidney deficiency subjects and 1 of 161 (0.6%) controls (P = 0.000, OR = 16.45). Furthermore, in pooled genotype analysis, I232IT and I232TT homozygotes were significantly enriched in kidney deficiency individuals compared with the controls (P = 0.000, OR = 3.79). Frequency of T allele was associated with kidney deficiency RA population (P = 0.000, OR = 3.18). Conclusion. This study confirmed that kidney deficiency was closely associated with disease activity and autoimmune disorder in RA. Kidney deficiency in RA is first to reveal a strong genetic link to Fc gamma RIIb variants.

• 出版日期2016
• 单位广州中医药大学第一附属医院