Nephroprotection, fact or fiction?

作者：Krummel Thierry^*; Faller Anne Laure; Bazin Dorothee; Hannedouche Thierry

来源：Presse Medicale, 2011, 40(11): 1037-1042.

DOI：10.1016/j.lpm.2011.04.021

Clinical studies of the last 15 years have shown the benefit of pharmacological interventions on the progression of chronic kidney disease, confirming the concept of nephroprotection. Pharmacological blockade of the renin angiotensin system remains the cornerstone of the nephroprotective treatment but the benefits and limitations ore now better defined.
The RAS blockers are all the more efficient than the proteinuria is abundant and nephroprotection is obtained in proportion to the reduction in proteinuria.
Combinations of ACEI + ARA are not validated and their use should be considered only under the supervision of a specialist when optimal monotherapy has failed.
The target blood pressure has been the subject of recent controversies, particularly in type 2 diabetic patients with nephropothy. The target should be individualized based on the main risk, renal or cardiovascular.
Recent maneuvers have also shown a nephroprotective effect, including the correction of metabolic acidosis with sodium bicarbonate.

• 出版日期2011-11