Long non-coding RNA AK021444 correlates with poor prognosis and promotes cell proliferation in colorectal cancer

作者：Yang, Peng; Rui, Qiang; Xu, Zi-Peng; Chen, Tao; He, Zhen-Yu^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(2): 3033-3040.

• LncRNA-AK021444
• colorectal cancer
• in situ hybridization

Long non-coding RNAs (lncRNAs) are aberrantly expressed in many diseases including cancer. Our previous studies suggested that lncRNA-AK021444 specificity expressed in Metastatic lymph node of colorectal cancer. However, the relationship between the clinical parameters and molecular mechanism of lncRNA-AK021444 in colorectal cancer (CRC) remain largely unknown. In the present study, we found that lncRNA-AK021444 was significantly related with CRC tumor size, lymph node metastasis, and increased death using in situ hybridization (ISH) method of 90 paired CRC specimens. Lentiviral vector-mediated lncRNA-AK021444 overexpression was employed in CRC cell line HCT116. Our study demonstrated that lncRNA-AK021444 overexpression regulated cell proliferation and apoptosis of CRC, which might be meaningful with regards to target therapy in CRC.

• 出版日期2016
• 单位南京医科大学