A model for generating synthetic arterial blood pressure

作者：Mahdi A^*; Clifford G D; Payne S J

来源：Physiological Measurement, 2017, 38(3): 477-488.

DOI：10.1088/1361-6579/aa51b8

• synthetic ABP
• systolic pressure
• diastolic pressure
• baroreflex
• heart rate variability

A new model capable of simulating many important aspects of human arterial blood pressure (ABP) is proposed. Both data-driven approach and physiological principles have been applied to describe the time series of diastolic, systolic, dicrotic notch and dicrotic peak pressure points. Major static and dynamic features of the model can be prescribed by the user, including heart rate, mean systolic and diastolic pressure, and the corresponding physiological control quantities, such as baroreflex sensitivity coefficient and Windkessel time constant. A realistic ABP generator can be used to compile a virtual database of signals reflecting individuals with different clinical conditions and signals containing common artefacts. The ABP model permits to create a platform to assess a wide range of biomedical signal processing approaches and be used in conjunction with, e.g. Kalman filters to improve the quality of ABP signals.

• 出版日期2017-3