Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect?

作者：Urbina Blanco Cesar A; Skibinski Maciej; O'Hagan David^*; Nolan Steven P

来源：Chemical Communications, 2013, 49(65): 7201-7203.

DOI：10.1039/c3cc44312d

The gem-difluoromethylene (CF2) group significantly accelerates ring-closing metathesis of 1,8-nonadienes relative to the methylene (CH2) group demonstrating similar rate accelerations to that observed for the classic Thorpe-Ingold substituents, diester malonates and ketals.

• 出版日期2013