New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

作者：Jiang, Bei; Wang, Wen-Jing; Li, Man-Ping; Huang, Xiao-Jun; Huang, Feng; Gao, Hao; Sun, Ping-Hua; He, Ming-Fang; Jiang, Zheng-Jin; Zhang, Xiao-Qi^*; Ye, Wen-Cai

来源：Bioorganic & Medicinal Chemistry Letters, 2013, 23(13): 3879-3883.

DOI：10.1016/j.bmcl.2013.04.072

• Alpinia oxyphylla
• Zingiberaceae
• Noreudesmane sesquiterpenoid
• Microglia
• Neuroprotection

The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells.

• 出版日期2013-7-1
• 单位暨南大学; 南京工业大学