Association between IL-1+3954C/T polymorphism and myocardial infarction risk: A meta-analysis

作者：Fang Yizhen; Xie Huabin^*; Lin Zhiyuan

来源：Medicine, 2018, 97(30): e11645.

DOI：10.1097/MD.0000000000011645

• IL-1
• meta-analysis
• myocardial infarction
• polymorphism

Background:Many studies have reported that the IL-1+3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1+3954C/T and MI susceptibility, we performed a meta-analysis.Methods:We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.Results:Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1+3954C/T in an allelic comparison (T vs C: OR=1.13, 95% CI 1.02-1.25, I-2=0%, P-H=.448) and in a dominant model (TC+TT vs CC: OR=1.15, 95% CI 1.02-1.30, I-2=0%, P-H=.880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR=1.16, 95% CI 1.04-1.29, I-2=0%, P-H=.701), homozygote model (TT vs CC: OR=1.36, 95% CI 1.04-1.79, I-2=0%, P-H=.673), and dominant model (TC+TT vs CC: OR=1.17, 95% CI 1.02-1.33, I-2=0%, P-H=.851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data.Conclusion:Our meta-analysis proved that IL-1+3954C/T is associated with MI susceptibility, especially among Caucasian populations.

• 出版日期2018-7
• 单位厦门大学