Associations between the insertion/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: A meta-analysis

作者：Song Gwan Gyu; Kim Jae Hoon; Lee Young Ho^*

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2015, 16(1): 211-218.

DOI：10.1177/1470320313485897

• Angiotensin-converting enzyme
• meta-analysis
• polymorphism
• abdominal aortic aneurysm

Introduction: The purpose of this study is to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to aortic aneurysms (AAs).
Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and all AAs and abdominal aortic aneurysms (AAAs).
Results: Ten studies consisting of 2784 cases and 2682 controls were available for the meta-analysis. Meta-analysis showed a significant association between the D allele and all types of AA (OR 1.378, 95% CI 1.103-1.723, p = 0.005) and AAA (OR 1.274, 95% CI 1.004-1.617, p = 0.046). Meta-analysis of both the DD genotype and the DD vs. II genotype showed an association with AAAs. Stratification by ethnicity indicated an association between the D allele of the ACE I/D polymorphism and AAAs in Europeans (OR = 1.338, 95% CI = 1.026-1.745, p = 0.031), but not in Asians (OR = 0.927, 95% CI = 0.660-1.303, p = 0.663). Furthermore, analysis using the recessive model, dominant model, and homozygote contrast all showed the same pattern for the D allele.
Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to AAAs in European populations.

• 出版日期2015-3