Preparation of ruthenium azido complex containing a Tp ligand and ruthenium-catalyzed cycloaddition of organic azides with alkynes in organic and aqueous media: Experimental and computational studies

作者：Wang Tsang Hsiu; Wu Feng Ling; Chiang Guan Ru; He Sheng Ting; Lo Yih Hsing^*

来源：Journal of Organometallic Chemistry, 2014, 774: 57-60.

DOI：10.1016/j.jorganchem.2014.09.038

• Tp
• Azide-alkyne cycloaddition
• Ruthenium azido
• Click chemistry

The catalytic activity of a series of ruthenium azido complexes containing Tp ligands has been evaluated for the cycloaddition of terminal alkynes and azides to give selectively 1,5-disubstituted 1,2,3-triazoles. The complex Tp(PPh3)(EtNH2)RuN3 (2, Tp = HB(pz)(3), pz = pyrazolyl) was found to be an effective catalyst for the cycloaddition reactions. In the presence of complex 2, azides reacted with a range of terminal alkynes containing various functionalities to selectively produce 1,5-disubstituted 1,2,3-triazoles. Theoretical calculations support the proposed mechanism.

• 出版日期2014-12-15